NVIDIA and UW Institute for Protein Design Release RFD4-Proteina Open Model

NVIDIA on Wednesday announced a set of healthcare and life sciences collaborations at GTC Berlin, led by RFD4-Proteina, a new open protein design model built with the UW Medicine Institute for Protein Design.

RFD4-Proteina
RFD4-Proteina is an NVIDIA BioNeMo open model that combines programmable protein design with search, letting scientists and agents generate, search and refine designs using molecular inputs, constraints and scoring objectives. NVIDIA says that in testing reported in the research draft, the model achieved higher computational design success rates and generation throughput than the evaluated baselines across four benchmark suites: protein binding, small-molecule binding, enzyme scaffolding and DNA binding. It is available today through partners including Amazon Bio Discovery, Anthropic's Claude Science, Benchling, Databricks, Google Cloud, Hugging Face, Nebius, OpenAI and Tamarind Bio.

Siemens Healthineers and adaptive radiotherapy
Siemens Healthineers and NVIDIA are collaborating on the next generation of adaptive radiotherapy. Nemotron open models are being explored for agentic treatment co-planning, which could be combined with CUDA-accelerated dose calculation for patient-specific simulation and the Holoscan platform for live sensor data. "Treatment should adapt to the patient, not the other way around," said Arthur Kaindl, head of Varian, the Siemens Healthineers cancer-care business.

Scientific agents
Benchling, Biolevate, Boltz, Automata, Hologen and Therna Biosciences are using BioNeMo, Nemotron and other NVIDIA technologies to build scientific agents and tools for drug design and lab workflows. Genedata's AI co-scientist will coordinate protein design and testing in the protein design foundry within Danaher's autonomous lab, using RFD4-Proteina.

Hospital operations in Europe

Avelios, Corti, Dedalus, Dawn Health and Sword are building on Nemotron for AI scribes, clinical support and patient services. PolyAI is using NVIDIA Agent Toolkit for a multilingual dialog deployment with Corilus, whose network spans more than 70,000 healthcare professionals in Belgium and France. Apian and VitVio are using Cosmos and Omniverse to build hospital digital twins.